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. 2015 Apr 7;6:155. doi: 10.3389/fimmu.2015.00155

Figure 6.

Figure 6

Plasma DAMPs increase after Stx2 challenge in mice. Mice were challenged i.p. with 1 ng/20 g body weight Stx2 [bold dashed line in (A), black squares in (B–F), n = 45] or saline [solid line in (A), open circle in (B), n = 15] on Day 0 and Day 3 and monitored for (A) survival and (B) plasma BUN. Plasma histones (C,D) and HMGB1 (E,F) were measured by ELISA. One group received a bolus dose of anti-histone BWA3 (400 μg i.p.) before challenge [(D,F); n = 5]. Survival was not influenced by BWA3 [(A), dotted; n = 5]. *p < 0.05, **p < 0.01, ***p < 0.001.