Fig. 3.

Pharmacological inhibition of the orexin-1 receptor reduces excessive ethanol (EtOH) consumption and blood EtOH concentration (BEC). Both the 5.0 mg/kg and 10.0 mg/kg doses of SB-334867 (SB) protected against excessive EtOH consumption during the first hour of testing relative to vehicle-treated controls; however, only the 10.0 mg/kg dose caused a significant reduction in EtOH drinking across the full 2-hour test period (A). Prior treatment with the 10.0 mg/kg dose of SB caused a significantly lower BEC relative to vehicle-treated controls (B). * denotes p < 0.05 relative to vehicle group at the same time point; †denotes p < .05 relative to 5.0 mg/kg group at the same time point. Data are presented as mean ± SEM.