Table 2.
Gene | Gene Symbol |
KO LFDa Malec |
WT HFDa Malec |
KO HFDb Malec |
KO LFDa Femaled |
KO HFDb Femaled |
---|---|---|---|---|---|---|
Endocrine Regulated | ||||||
Cytochrome P450 7b1 | Cyp7b1 | 11.4** | 3.4 | 4.6* | 2.7 | 2.9 |
Adropin | Enho | 2.2 | 2.1 | 2.0 | 5.5 | 4.3 |
Epidermal growth factor receptor | Egfr | 3.1** | 1.4 | 2.2** | 2.7 | 6.4 |
Growth hormone receptor | Ghr | 1.3 | 1.4 | 1.5 | −1.1 | 1.0 |
Hepatocyte nuclear factor 6 | Onecut1 | 2.8** | 1.0 | 4.5** | 1.2 | 2.5 |
Hydroxy-delta-5-steroid dehydrogenase | Hsd3b4 | 13.0* | 6.1 | 2.2 | 5.6 | 3.1 |
Major urinary protein 1 | Mup1 | 7.5* | 3.8 | 3.7 | −1.2 | 1.5 |
Solute carrier organic anion transporter | Slco1a1 | 5.2* | 4.2 | 1.7 | 6.6 | 6.9 |
Peroxisome proliferator-activated receptor γ | Pparγ | −4.5** | −1.2 | −4.6** | −1.5 | −2.7 |
Energy Homeostasis | ||||||
Acetyl-CoA carboxylase beta | Acacb | 1.4 | −3.2* | −1.9 | −1.3 | 1.5 |
Fatty acid synthase | Fasn | 1.3 | −2.0 | −1.5 | −2.9 | 1.2 |
Malic enzyme 1 | Me1 | 1.0 | −1.7 | −7.5* | −2.2 | −1.9 |
Stearoyl-CoA desaturase 1 | Scd1 | 1.3 | −3.2* | −6.0** | −1.7 | −1.9 |
Pyruvate dehydrogenase kinase 4 | Pdk4 | −1.9 | −3.1* | −3.7** | −2.4 | −1.9 |
Elongation of very long chain fatty acids | Elovl5 | −1.5 | −1.6 | −2.1* | −1.3 | −1.7 |
Fibroblast growth factor 21 | Fgf21 | −3.1 | −2.9* | −2.9* | −1.8 | −2.9 |
Insulin-like growth factor binding protein 1 | Igfbp1 | −1.7 | −3.5 | −5.1* | 1.0 | −2.3 |
Insulin-like growth factor 1 | Igf1 | −1.1 | 1.0 | 1.1 | −1.5 | 1.4 |
STAT-induced STAT inhibitor 2 | Socs2 | 1.8 | −2.3 | 5.4* | 3.4 | 3.9 |
Glycogen Synthesis | ||||||
PP1 regulatory subunit 3b | Ppp1r3b | 2.2 | 1.8 | 1.0 | −3.7 | 1.0 |
PP1 regulatory subunit 3c | Ppp1r3c | 3.8* | 1.6 | 2.4 | −2.7 | −1.3 |
PP1 regulatory subunit 3g | Ppp1r3g | −4.6* | −2.4 | −5.9** | 9.7 | −4.3 |
Glycogen-branching enzyme | Gbe1 | −1.2 | 1.2 | −2.3 | −2.2 | −1.6 |
Liver glucose transporter, type 2 | Slc2a2 | 1.7 | 1.9 | 1.0 | −1.3 | −1.3 |
Glucose transporter type 4 | Slc2a4 | 2.1 | −3.2 | −1.4 | −6.0 | −23.5 |
PPARα activity | ||||||
Peroxisome proliferator-activated receptor α | Pparα | 1.0 | 1.0 | −1.2 | 1.8 | −1.2 |
Peroxisomal CoA diphosphatase 7 | Nudt 7 | 2.3** | 1.3 | 2.4** | −1.3 | 1.8 |
Acyl-CoA thioesterase 1 | Acot1 | −4.4** | 1.5 | −4.7 | 3.0 | −1.6 |
Cytochrome P450 4a10 | Cyp4a10 | −11.7 | 1.7 | −11.2 | 1.6 | −1.5 |
Cytochrome P450 4a14 | Cyp4a14 | −43.4** | 1.4 | −66.3** | 1.4 | −1.8 |
Fat stimulatory protein/FSP27 | Cidec | −4.7* | −1.9 | −4.8** | −2.0 | 1.1 |
Fatty acid translocase | CD36 | −7.6** | −1.7 | −5.5** | −7.5 | −6.3 |
G0/G1 Switch 2/Lipase activator | G0s2 | −2.5* | 1.3 | −2.8* | −2.3 | −1.8 |
Kruppel-like factor 6 | Klf6 | −2.9** | −2.4 | −1.6 | −1.4 | 1.1 |
Lipin phosphatidase 2 | Lpin 2 | −1.7* | 1.4 | −2.4 | 2.1 | −1.1 |
Osteopontin | Spp1 | −2.6* | −2.0 | −1.2 | −1.5 | −1.9 |
P8 transcription factor | Nupr1 | −5.1** | −5.5 | −1.3 | −4.7 | 1.3 |
Very-low-density-lipoprotein receptor | Vldlr | −9.1** | −1.2 | −3.1* | −4.3 | −2.4 |
Phosphatidyl choline transferase protein | Pctp | −1.9* | 1.7 | −2.3** | −1.2 | −1.3 |
Peroxisomal biogenesis factor 11 alpha | Pex11a | −2.8** | 1.2 | −2.4 | 1.0 | −2.2 |
Acyl-CoA thioesterase 13 | Them2 | −1.9 | 2.0 | −1.8 | −1.5 | −1.2 |
Oxidant Stress | ||||||
Glutathione S-transferase pi 1 | Gstp1 | 2.1** | −1.1 | 3.1** | 1.0 | −1.2 |
Selenium binding protein 1 | Selenbp1 | 2.4** | 1.2* | 2.5** | −1.3 | 1.1 |
Gamma-interferon-induced monokine | Cxcl9 | −3.0** | −1.4 | −4.0** | −2.2 | −2.3 |
Gamma-interferon-induced protein | Cxcl10 | −3.8* | −1.9 | −3.6* | −3.2 | −2.3 |
Expression levels are calculated relative to WT, LFD
Expression levels are calculated relative to WT, HFD.
Male (n=3)
female (n=2) mice were fed the diets for 11 and 36 weeks, respectively, post-weaning. Data represents fold change.
p-value < 0.05
p-value < 0.01.