Table 2.

Liver microarray expression data for genes linked to obesity and diabetes.

Gene	Gene Symbol	KO LFDa Malec	WT HFDa Malec	KO HFDb Malec	KO LFDa Femaled	KO HFDb Femaled
Endocrine Regulated
Cytochrome P450 7b1	Cyp7b1	11.4**	3.4	4.6*	2.7	2.9
Adropin	Enho	2.2	2.1	2.0	5.5	4.3
Epidermal growth factor receptor	Egfr	3.1**	1.4	2.2**	2.7	6.4
Growth hormone receptor	Ghr	1.3	1.4	1.5	−1.1	1.0
Hepatocyte nuclear factor 6	Onecut1	2.8**	1.0	4.5**	1.2	2.5
Hydroxy-delta-5-steroid dehydrogenase	Hsd3b4	13.0*	6.1	2.2	5.6	3.1
Major urinary protein 1	Mup1	7.5*	3.8	3.7	−1.2	1.5
Solute carrier organic anion transporter	Slco1a1	5.2*	4.2	1.7	6.6	6.9
Peroxisome proliferator-activated receptor γ	Pparγ	−4.5**	−1.2	−4.6**	−1.5	−2.7
Energy Homeostasis
Acetyl-CoA carboxylase beta	Acacb	1.4	−3.2*	−1.9	−1.3	1.5
Fatty acid synthase	Fasn	1.3	−2.0	−1.5	−2.9	1.2
Malic enzyme 1	Me1	1.0	−1.7	−7.5*	−2.2	−1.9
Stearoyl-CoA desaturase 1	Scd1	1.3	−3.2*	−6.0**	−1.7	−1.9
Pyruvate dehydrogenase kinase 4	Pdk4	−1.9	−3.1*	−3.7**	−2.4	−1.9
Elongation of very long chain fatty acids	Elovl5	−1.5	−1.6	−2.1*	−1.3	−1.7
Fibroblast growth factor 21	Fgf21	−3.1	−2.9*	−2.9*	−1.8	−2.9
Insulin-like growth factor binding protein 1	Igfbp1	−1.7	−3.5	−5.1*	1.0	−2.3
Insulin-like growth factor 1	Igf1	−1.1	1.0	1.1	−1.5	1.4
STAT-induced STAT inhibitor 2	Socs2	1.8	−2.3	5.4*	3.4	3.9
Glycogen Synthesis
PP1 regulatory subunit 3b	Ppp1r3b	2.2	1.8	1.0	−3.7	1.0
PP1 regulatory subunit 3c	Ppp1r3c	3.8*	1.6	2.4	−2.7	−1.3
PP1 regulatory subunit 3g	Ppp1r3g	−4.6*	−2.4	−5.9**	9.7	−4.3
Glycogen-branching enzyme	Gbe1	−1.2	1.2	−2.3	−2.2	−1.6
Liver glucose transporter, type 2	Slc2a2	1.7	1.9	1.0	−1.3	−1.3
Glucose transporter type 4	Slc2a4	2.1	−3.2	−1.4	−6.0	−23.5
PPARα activity
Peroxisome proliferator-activated receptor α	Pparα	1.0	1.0	−1.2	1.8	−1.2
Peroxisomal CoA diphosphatase 7	Nudt 7	2.3**	1.3	2.4**	−1.3	1.8
Acyl-CoA thioesterase 1	Acot1	−4.4**	1.5	−4.7	3.0	−1.6
Cytochrome P450 4a10	Cyp4a10	−11.7	1.7	−11.2	1.6	−1.5
Cytochrome P450 4a14	Cyp4a14	−43.4**	1.4	−66.3**	1.4	−1.8
Fat stimulatory protein/FSP27	Cidec	−4.7*	−1.9	−4.8**	−2.0	1.1
Fatty acid translocase	CD36	−7.6**	−1.7	−5.5**	−7.5	−6.3
G0/G1 Switch 2/Lipase activator	G0s2	−2.5*	1.3	−2.8*	−2.3	−1.8
Kruppel-like factor 6	Klf6	−2.9**	−2.4	−1.6	−1.4	1.1
Lipin phosphatidase 2	Lpin 2	−1.7*	1.4	−2.4	2.1	−1.1
Osteopontin	Spp1	−2.6*	−2.0	−1.2	−1.5	−1.9
P8 transcription factor	Nupr1	−5.1**	−5.5	−1.3	−4.7	1.3
Very-low-density-lipoprotein receptor	Vldlr	−9.1**	−1.2	−3.1*	−4.3	−2.4
Phosphatidyl choline transferase protein	Pctp	−1.9*	1.7	−2.3**	−1.2	−1.3
Peroxisomal biogenesis factor 11 alpha	Pex11a	−2.8**	1.2	−2.4	1.0	−2.2
Acyl-CoA thioesterase 13	Them2	−1.9	2.0	−1.8	−1.5	−1.2
Oxidant Stress
Glutathione S-transferase pi 1	Gstp1	2.1**	−1.1	3.1**	1.0	−1.2
Selenium binding protein 1	Selenbp1	2.4**	1.2*	2.5**	−1.3	1.1
Gamma-interferon-induced monokine	Cxcl9	−3.0**	−1.4	−4.0**	−2.2	−2.3
Gamma-interferon-induced protein	Cxcl10	−3.8*	−1.9	−3.6*	−3.2	−2.3

^aExpression levels are calculated relative to WT, LFD

^bExpression levels are calculated relative to WT, HFD.

^cMale (n=3)

^dfemale (n=2) mice were fed the diets for 11 and 36 weeks, respectively, post-weaning. Data represents fold change.

^*p-value < 0.05

^**p-value < 0.01.