Table 4.
Liver genes that are conserved between male and female mice fed the LFD, but are affected by Cyp1b1 deletion, and their impact on Type 2 diabetes.
| Gene | Effect of Cyp1b1-ko |
Gene Function | Impact of gene on Type 2 Diabetes |
Ref |
|---|---|---|---|---|
| Scd1 | − | FA desaturation | KO increases GT | 16 |
| Pdk4 | − | Pyruvate to Acetyl CoA | KO increases GT | 61 |
| Me1 | − | Malate/NADP to Pyruvate | KO increases GT | 59 |
| Map4k4 | − | TNF-activated kinase inhibits insulin | KO increases GT | 86 |
| Pparγ | − | Stimulates TG synthesis | Liver KO lowers SH | 87 |
| Spp1 | − | Sustains PPARγ/lipid droplets | KO lowers SH, glucose | 88 |
| Gas6 | − | Released from Kupffer cells/ increase FA oxidation | KO lowers SH, inflamation | 89 |
| Rgs16 | − | G protein activator | KO increases FA oxidation | 90 |
| Vldlr | − | Very low density lipoprotein receptor | KO lowers SH | 91 |
| Socs2 | + | Ubiquitin ligase, negative regulator of JAK/STAT | KO decreases insulin sensitivity | 92 |
| G0s2 | − | PNPLA2 inhibitor | Tg stimulates SH | 51 |
| Cidec | − | Binds lipid droplets, mediates PPARγ effects | Tg stimulates SH | 93 |
| Lpin2 | − | Lipid phosphatase/PPAR co-activator | SiRNA suppresses SH | 50 |
| Cyp7b1 | + | Bile acid synthesis | Tg stimulation lowers glucose | 94 |
| Slco1a1 | + | Bile acid transport | Tg stimulation lowers glucose | 94 |
| Cyp1b1-effects directly link to decreased T2D/SH | ||||
| Hamp2 | − | Hepcidin2/ Fe stimulant | Serum hepcidin linked to T2D | 95 |
| Hhex | + | Liver homeobox regulator | Mutant human marker for T2D | 96 |
Type 2 diabetes = T2D
Glucose tolerance = GT
Steatotic hepatitis = SH
Transgene = Tg