Relative transmission ratios (RTRs) are displayed for variants categorized by their functionality (blue: loss-of-function [LOF] variants; red: MODERATE-effect variants; and green: LOW-effect variants), minor allele frequencies (private, rare, or common), and gene intolerance. Detailed definition for LOF, MODERATE-, and LOW-effect variants is provided in the Supplemental Experimental Procedures. *p < 0.05. Error bars indicate 95% confidential intervals. p values for RTRs were calculated by one-sided permutation analysis with random shuffling of the case-control status.