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Graphical illustration of the most prominent morphological features of apoptotic and necrotic cell death mechanisms. Nuclei changes (karyorrhexis), cytoplasm shrinkage, and blebbing are the most evident descriptors of apoptosis. On the other hand, necrosis is clearly recognizable by cell swelling (loss of osmotic barrier) leading to the plasma membrane (PM) breakage and final release of the inner soluble content and nuclei karyolysis.
