Table 3.
Virus-eEF1A interplay.
| Virus | Description of eEF1A/viral protein interaction | Reference |
|---|---|---|
| HIV | eEF1A part of HIV-1 virion and reverse transcriptase complex | (77, 89, 90, 93) |
| eEF1A also interacts with Nef and modulate apoptosis in MDMs | ||
| HBV | HBx interacts with eEF1A1 resulting in blockade of actin bundling | (97) |
| HDV | HDV genome also interacts with eEF1A1 | (98) |
| HPV 38 | E7 protein interacts with both eEF1A1 and eEF1A2. The interaction is associated with cellular immortalization and transformation of primary keratinocytes | (99) |
| WNV | eEF1A interacts with the 3′stem–loop region of the viral genomic RNA and favors replication | (100, 101) |
| DENV | Viral genomic RNA sequesters eEF1A and hence decreases the concentration of Sphk1, thereby governing cell survival | (102) |
| TGEV | eEF1A interacts with the nucleocapsid of the virus and favors virus replication | (103) |
| VSV | eEF1A is found within the virion | (104) |
| Vaccinia virus | eEF1A as a part of mature virion | (105, 106) |
| CMV | eEF1A found to be as a part of virion proteome | (107, 108) |
| SARS-CoV | eEF1A found in mature virion | (109) |
HIV, human immunodeficiency virus; MDMs, monocyte-derived macrophages; HBV, hepatitis B virus; HDV, hepatitis delta virus; HPV, human papillomavirus; WNV, West Nile virus; DENV, dengue virus; VSV, vesicular stomatitis virus; CMV, cytomegalovirus; TGEV, transmissible gastroenteritis coronavirus; SARS, severe acute respiratory syndrome-associated coronavirus (SARS-CoV).