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. 2015 Apr 7;6:77. doi: 10.3389/fneur.2015.00077

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Copyright © 2015 Sun, Liu, Zhang, Zhou, Manohar, Winchester, Miranda and Salvi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ICA-105665 on compound action potential (CAP) threshold shifts induced by salicylate (SS). (A) Typical CAP response recorded from the round window of cochlea elicited by a tone-burst stimulus (8 kHz, 80 dB SPL). (B,C) Significant threshold shifts of CAP were induced by high doses of SS (250 mg/kg, i.p.). ICA-105665 (10 mg/kg, i.p., n = 7) treatment caused a significant reduction of CAP threshold shifts at 8, and 32 kHz on 1 h, and 8, 16, and 32 kHz on 2 h after salicylate injection (Student’s t-test, df = 11, P values were listed in Table 1).