Figure 4.
Efficiency of phage 1513 in vivo. Survival curves of the infected mice treated with either PBS or phages at different multiplicities of infection (MOI). A group of 10 mice were inoculated via the intranasal route with 2 × 108 CFU/mouse K. pneumoniae. Various doses of phage 1513 were administrated intranasally 2 h after infection. Survival curves were compared for significance with the log-rank test of the results obtained from the following parameters: from the phage 1513 (2 × 107 PFU/mouse) treatment group versus those from the control group (P = 0.0058), from the phage 1513 (2 × 108 PFU/mouse) treatment group versus those from the control group (P = 0.0018), and from the phage 1513 (2 × 109 PFU/mouse) treatment group versus those from the control group (P = 0.0002).