Table 2.
Overview of MBL concentrations and MBL2 genotype.
| Healthy | NICU (neοnatal intensive care unit) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (number 150) | Total (number 134) | Term (number 83) | Preterm (number 51) | |||||||
| MBL (ng/mL) | MBL (ng/mL) | MBL (ng/mL) | MBL (ng/mL) | |||||||
| n (%) | Median (range) | n (%) | Median (range) | P1, P2 values* | n (%) | Median (range) | n (%) | Median (range) | P3, P4 values# | |
| MBL2 genotype | ||||||||||
| YA/YΑ | 50 (33.3) | 1725 (100–4110) |
42 (31.3) | 1515 (100–3000) |
0.798 0.082 |
23 (27.7) | 1610 (190–3000) |
19 (37.3) | 1190 (100–2200) |
0.407 0.033 |
| YA/ΧA | 26 (17.3) | 1290 (550–1990) |
21 (15.7) | 1230 (40–2080) |
0.750 0.480 |
13 (15.7) | 1350 (740–2080) |
8 (15.7) | 1055 (40–1690) |
0.998 0.082 |
| ΧA/ΧA | 6 (4.0) | 885 (700–1600) |
9 (6.7) | 600 (340–1790) |
0.333 0.088 |
7 (8.4) | 600 (420–1090) |
2 (3.9) | 1065 (340–1790) |
0.341 NA |
| YA/O | 42 (28.0) | 235 (10–2440) |
33 (26.7) | 180 (40–1350) |
0.623 0.452 |
24 (28.9) | 210 (40–1350) |
9 (17.6) | 105 (50–710) |
0.247 0.384 |
| XA/O | 16 (10.7) | 45 (10–430) |
17 (12.7) | 30 (10–210) |
0.637 0.065 |
11 (13.3) | 10 (10–210) |
6 (11.8) | 10 (10–200) |
0.825 0.339 |
| O/O | 10 (6.7) | 10 (10–290) |
12 (9.0) | 10 (10–200) |
0.505 0.473 |
5 (6.0) | 10 (10–10) |
7 (13.7) | 10 (10–200) |
0.169 1.000 |
|
| ||||||||||
| MBL2 genotype groups | ||||||||||
| High YA/YA, YA/XA |
76 (50.7) | 1600 (100–4110) |
63 (47.0) | 1350 (40–3000) |
0.719 0.068 |
36 (43.4) | 1600 (190–3000) |
27 (52.9) | 1170 (40–2200) |
0.521 0.012 |
| Medium XA/XA, YA/O |
48 (32.0) | 260 (10–2440) |
42 (31.3) | 265 (10–1790) |
0.932 0.833 |
31 (37.3) | 330 (40–1350) |
11 (21.6) | 180 (50–1790) |
0.160 0.367 |
| Low XA/O, O/O |
26 (17.3) | 25 (10–430) |
29 (21.6) | 10 (10–210) |
0.451 0.044 |
16 (19.3) | 10 (10–210) |
13 (25.5) | 10 (10–200) |
0.499 0.569 |
|
| ||||||||||
| MBL functional deficiency | P5 value∧ | P6 value∧ | ||||||||
|
| ||||||||||
| MBL levels ≤150 ng/mL |
30 (10.0) | 42 (31.3) | 0.091 | 24 (28.9) | 18 (35.3) | 0.578 | ||||
| MBL levels ≤400 ng/mL |
61 (40.7) | 62 (46.3) | 0.550 | 35 (42.2) | 27 (52.9) | 0.465 | ||||
| MBL levels ≤700 ng/mL |
68 (45.3) | 72 (53.7) | 0.411 | 44 (53.0) | 28 (54.9) | 0.907 | ||||
*Statistical significance P1 and P2 refer to comparison of MBL2 genotypes and MBL concentrations between NICU patients with healthy controls (chi-square and Mann-Whitney U test, resp.); # P3 and P4 refer to comparison of MBL2 genotypes and MBL concentrations between term and preterm neonates of NICU (chi-square and Mann-Whitney U test, resp.); ∧ P5 and P6 refer to comparison of MBL functional deficiency (using 3 different cut-offs) between healthy and NICU neonates and between term and preterm neonates of NICU, respectively (chi-square test).