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. Author manuscript; available in PMC: 2015 Apr 7.
Published in final edited form as: J Allergy Clin Immunol. 2014 Jun 27;134(4):967–9.e7. doi: 10.1016/j.jaci.2014.05.009

FIG 1.

FIG 1

Immunoglobulin binding to conformational and linear epitopes of Jun a 1. The % of binding due to discontinuous epitopes is indicated for each serum. These were computed from the relative amount of native (◆) and guanidine-denatured Jun a 1 (○) required to inhibit by 50% the binding of patient IgE to native Jun a 1 on ELISA plates (A) and to induce mast cell degranulation of RBL SX-38 cells sensitized with patient sera (B). RBL, Rat basophilic leukemia.