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Penetration of water and change in conformation of Glu35 in the internal cavity near Trp108: (a) from 0.1 to 890 MPa and at 920 MPa for the (GlcNAc)4 complex and (b) for the four molecules at 950 MPa. The internal cavity is represented as a pink surface. The green mesh shows the difference electron-density map calculated by omitting the water that penetrates and a Glu35 side chain. Maps are contoured at (a) 3.0σ and (b) 2.5σ.
