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. Author manuscript; available in PMC: 2015 Apr 7.
Published in final edited form as: Genes Cells. 2013 Nov 19;19(1):28–51. doi: 10.1111/gtc.12104

Figure 9.

Figure 9

Proposed model for the role of CCAR/CoCoA in the bypass mechanism of GATA1- and MED1-mediated transcriptional activation. CCAR1, CoCoA, and MED1(681–715) interact with the CF domain either competitively or simultaneously. CCAR1 and CoCoA interact with the CF domain of GATA1 and the N-terminal domain of MED1 simultaneously via multiple interfaces. MED1-led Mediator then recruits RNA polymerase II, eventually forming a preinitiation complex for transcription initiation. The multiple pathways that underlie the GATA1-MED1 axis may help to fine-tune the coupling between GATA1 and the basal transcriptional machinery.