Table 2.

HIV-1 NNRTI surveillance drug resistance mutations: prevalence in RTI-naive and RTI-treated persons according to subtype

		RTI-naive persons*								RTI-treated persons†
		A	AE	AG	B	C	D	F	G	A	AE	AG	B	C	D	F	G
Pos‡	AA§	519	1043	720	4,545	1,950	224	207	209	296	746	362	10,942	793	261	289	630
L100	I	0	0	0	0	0	0	0	0	2	1.9	1.7	1.6	1	1.5	2.4	2.6
K101	E	0	0	0	0.1	0.1	0	0	0	3.7	5.7	6.7	2	3.8	2.3	4.2	1.6
N103	N	0.2	0	0	0.4	0.2	0	0	0	18	13	26	17	18	17	24	37
	S	0	0	0	0	0.1	0	0	0	0	0	0	0.3	0.3	0	0	0.3
V106	A	0	0	0	0	0	0	0	0	0	0	0	0.7	0	0	0.7	1.3
	M	0	0	0	0	0	0	0	0	0	1.1	0.6	0.2	9	0.8	1.4	0.3
Y181	C	0.2	0.1	0	0.1	0.1	0	0	0	8.3	9.4	7.8	7.9	9	5.4	15	12
	I	0	0.1	0	0	0	0	0	0	0.7	1.1	0	0.4	0.5	0	0.7	0.3
Y188	C	0	0	0.1	0	0	0	0	0	0	0	0	0.1	1	0.8	0	0.3
	H	0	0	0	0	0.1	0.5	0	0	0.7	0	0	0.2	0	0	0	0
	L	0	0.2	0	0	0.1	0	0	0	1.4	4.6	1.7	1.6	3.3	0.8	2.1	4.2
G190	A	0	0.1	0	0	0.1	0.5	0	0	11	13	4.5	4.5	9.2	7.7	4.6	5.3
	E	0	0	0	0	0.1	0	0	0	0	0.5	0	0.3	0.3	0	0.7	0.3
	Q	0	0	0	0	0	0	0	0	0	0	0	0.1	0	0	0	0
	S	0	0	0	0	0	0	0	0	0.7	1.3	5.6	1.1	1.3	0.8	1.4	0.3
P225	H	0	0	0	0	0	0	0	0	0	1.4	3.5	0.9	0.8	1.4	2.2	4
M230	L	0	0	0	0	0	0	0	0	0.8	0.3	1.8	0.5	1.3	0	0.8	1
P236	L	0	0	0.3	0.1	0	0	0	0	0	0	0	0.2	0.6	0	0	0

^*The header for columns 3–10 contains the number of sequences in the HIV Drug Resistance Database from untreated persons by subtype.

^†The header for columns 11–18 contains the number of sequences from treated persons according to subtype. The row entries contain the mutation prevalence (%) according to subtype and treatment using a set of publicly available sequences updated on the 1 October 2007.

^‡Pos, reverse transcriptase position preceded by the consensus residue.

^§AA, surveillance drug resistance mutation. RTI, reverse transcriptase inhibitor; SDRM, surveillance drug resistance mutation.