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. Author manuscript; available in PMC: 2015 Apr 7.
Published in final edited form as: Expert Opin Drug Deliv. 2014 Mar 20;11(5):711–721. doi: 10.1517/17425247.2014.897693

Figure 1.

Figure 1

Timeline for FUS experiments. Animals are prepared for FUS treatment by using chemical depilatory to remove the hair from the head and by inserting a catheter into the tail vein. A T2-MR image is acquired and the target locations for sonication are chosen (denoted by red dots). Microbubble contrast agent is diluted and injected immediately prior to the onset of sonication. FUS is applied using standard parameters (10ms pulses, 1 Hz pulse repetition frequency, 120s total duration). Following FUS, MRI contrast agent is injected and a contrast enhanced (CE)-T1 weighted MR images is acquired. The regions of hyperintensity correspond to areas where contrast agent move from the vasculature into the brain parenchyma and is used to confirm effective BBB opening with FUS.

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