Figure 2.

MRI has been the primary imaging modality for targeting and evaluating FUS treatments. Top panel – MR images from a mouse brain were taken using a 3.0T MR scanner (GE Healthcare). T2 weighted images were used to choose 4 sonication points in each hemisphere (red dots). Contrast enhanced T1 weighted images were used to confirm BBB opening had occurred in the target locations (red arrows).

Bottom panel – MR images from a mouse brain were taken using a 7.0T MR scanner (Bruker). T2 weighted images were used to target the bilateral hippocampus using 2 sonciations in each hemisphere (red dots). T1 weighted images were used to confirm BBB opening had occurred on target (red arrows).