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. 2015 Apr 7;10(4):e0121915. doi: 10.1371/journal.pone.0121915

Table 1. Simulation model inputs.

Model Input Point Estimate Low High Data Source Distribution
Exenatide 2 mg          
    Effectiveness          
        DURATION-6 Trial Reduction in HbA1c 1.28% 1.18% 1.38% [9] Beta
        Meta-Analysis Reduction in HbA1c 1.15% 1.00% 1.31% [10] Beta
    Discontinuation Rate
        Before Week 4 0% 0% 1% [9] Beta
        After Week 4 13.23% 10.59% 15.88% [9] Beta
    Drug Cost (2014 $USD)
        Monthly cost of exenatide 2 mg (4 Pack) $407 $367 $448 WAC Normal
    Adverse Event Rates
        Patients Experiencing 1+ Adverse Events 61.39% 49.11% 73.67% [9] Beta
        Gastrointestinal Disorders 39.93% 31.94% 47.92% [9] Beta
Liraglutide 1.8 mg
    Effectiveness
        DURATION-6 Trial Reduction in HbA1c 1.48% 1.38% 1.58% [9] Beta
        Meta-Analysis Reduction in HbA1c 1.18% 1.04% 1.32% [10]
    Discontinuation
        Before Week 4 3.33% 2.66% 4.00% [9] Beta
        After Week 4 9.78% 7.82% 11.74% [9] Beta
    Drug Cost (2014 $USD)
        Monthly cost of liraglutide 1.8 mg (30 Pack) $536 $482 $589 WAC Normal
        Needle cost $9 $8 $10 Assumption Normal
    Adverse Event Rates
        Patients Experiencing 1+ Adverse Events 64.89% 51.91% 77.87% [9] Beta
        Gastrointestinal Disorders 54.7% 43.78% 65.66% [9] Beta
Other Costs
    Adverse Event Costs (2014 $USD)
        Gastrointestinal Disorders $1,113 $890 $1,335 Expert Opinion Normal

HbA1c = glycated hemoglobin; $USD = United States dollars; WAC = wholesale acquisition cost