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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Histol Histopathol. 2014 Mar 28;29(9):1083–1092. doi: 10.14670/hh-29.1083

Figure 2.

Figure 2

Matrix stiffness induces integrin clustering and activation of PI3K and Rho in breast cancer cells. Integrin clustering enhances growth factor-dependent ERK activation and increases ROCK expression lever. Increased cell tension reduces turnover of lamin A. Accumulation of lamin A drives translocation of the retinoic acid receptor (RARG) into nucleus and RARG lead the transcription of Lamin-A. Rho and Lamin-A can translocate YAP/TAZ. YAP regulates the expression of several cytoskeletal regulators, including MLC.