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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Cancer Res. 2014 Sep 12;74(21):6205–6215. doi: 10.1158/0008-5472.CAN-14-1716

Fig. 4. Carbidopa, a benserazide analog, does not enhance repair or prevent anchorage-independent growth.

Fig. 4

(A) The chemical structure of carbidopa is shown. (B) Carbidopa was included in the chemical screen described in Fig. 1. The screening data is displayed and includes the percent increase in BER relative to the vehicle control for both methods of detection- imaging and plate reading. (C) The graph depicts the effect of carbidopa on BER activity relative to the untreated vehicle control using a small-scale BER assay for validation of screening results. Data are representative of three experiments; error bars denote s.d. (D) The bar graph displays colony formation for shCTRL- and shBRCA1-containing MCF7 cells (described in Fig. 3B) treated with vehicle control or increasing concentrations of carbidopa. Each bar represents the average of at least three experiments ± s.e.m.