Fig 6. Desflurane increases intrinsic excitability of granule cells.

A. GrC voltage responses to current injections (bottom traces 1 pA/step) in control conditions, during desflurane perfusion and following wash-out. Note the decreased number of current steps required to generate action potentials and the increased number of elicited spikes, concomitant with a reduced firing threshold (arrow). B. Comparison of spike waveform obtained in control condition (black), in the presence of desflurane (dark gray) and following wash-out (light gray). C. Histogram summarizes the variations induced by desflurane on the current needed to elicit spikes (current inj), spike threshold (spike thr), spike after hyperpolarization (spike AHP) and spike half-width (spike HW) (n = 7).