Table 1. Fold increase of the genes involved in the significant pathways obtained by gene expression profiling.
| Hemoglobins chaperon 1 | MTH 30nM/C | MTH 30nM+anti-microRNA-210/C | MTH 30nM+anti-microRNA-588/C |
|---|---|---|---|
| HBA1 | 6.13 | 1.04 | 5.99 |
| HBA2 | 7.12 | 1.09 | 6.76 |
| HBE1 | 1.60 | 0.97 | 1.36 |
| HBZ | 5.30 | 1.47 | 5.30 |
| ERAF | 18.24 | 1.62 | 14.30 |
| CPOX | 2.74 | 1.10 | 2.66 |
| HMBS | 2.74 | 1.12 | 2.89 |
| UROS | 2.56 | 1.32 | 2.47 |
| UROD | 1.57 | 1.12 | 1.54 |
| FECH | 2.09 | 0.78 | 1.82 |
| Erythroid differentiation Markers 2 | MTH 30nM/C | MTH 30nM+anti-microRNA-210/C | MTH 30nM+anti-microRNA-588/C |
| NFE2L3 | 3.08 | 1.00 | 2.99 |
| EPB49 | 3.58 | 1.13 | 3.40 |
| SLC4A1 | 39.72 | 1.23 | 29.53 |
The values referred to untreated K562 cells control.
1. HBA1 (hemoglobin alpha 1), HBA2 (hemoglobin alpha 2), HBE1 (hemoglobin epsilon 1), HBZ (hemoglobin zeta), ERAF (erythroid associated factor), CPOX (coproporphyrinogen oxidase), HMBS (hydroxymethylbilane synthase), UROS (uroporphyrinogen III synthase), UROD (uroporphyrinogen decarboxylase), FECH (ferrochelatase)
2. NFE2L3 nuclear factor erythroid-derived 2-like 3), EPB49 (erythrocyte membrane protein band 4.9), SLC4A1 (solute carrier family 4, anion exchanger, member 1 erythrocyte membrane protein band 3, Diego blood group).