Figure 7.

Model of Tox activity

Model summarizing the regulation and induced molecular effects of Tox as deduced from the literature (red arrows) and our own experiments (black arrows). We propose that activation of calcineurin signalling promotes Tox expression through nuclear transport of Nfat4, which results in Tox-induced transcriptional regulation of different sets of genes (some indicated) in PP or neurons (N) to ultimately control stem cell fate (left) or neurite outgrowth (right) through yet to be characterized cell-specific co-factors (X and Y).