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. 2015 Feb 23;34(7):940–954. doi: 10.15252/embj.201489642

Figure 4.

Figure 4

The apical α-βH Spectrin cytoskeleton may be mechanosensory in the wing imaginal disc
  • A Schematic diagram of central compression and circumferencial stretching in the third instar wing pouch.
  • B-D Third instar wing imaginal disc stained for beta-galactosidase expressed from the expanded.lacZ reporter gene (B), Crb (C) and Kst-YFP (D). Quantification of line intensity shown below. Note inverse correlation of Crb and Kst-YFP with ex.lacZ. Scale bars, 50 μm.
  • E, F Zoom of Kst-YFP cells under compression (E) and under stretch (F). Scale bars, 10 μm.
  • G Schematic diagram of the effect of force on the apical spectrin cytoskeleton leading to declustering of Crumbs complexes and reduced Hippo signalling.