Figure 3.

Inflammation promotes neurogenesis and regeneration in zebrafish

In zebrafish, inflammation elicited by immune cells leads to secretion of leukotriene C4 (LTC4, green circles), which bind to its receptor Cystlr1 on neural stem/progenitor cell (NSPC). LTC4/Cystlr1 signaling leads to transcriptional activation of zinc-finger transcription factor Gata3, which is a key molecule that promotes proliferation and regenerative neurogenesis. Chemokine signaling through Cxcr5 is also required for differentiation of proliferating NSPCs into neurons.