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. 2015 Apr 7;10(4):e0122415. doi: 10.1371/journal.pone.0122415

Fig 1. Effect of intracerebroventricular injection of Aβ1–42 aggregates on spatial learning memory in the Morris water-maze test.

Fig 1

(A) The experimental protocol. (B) Representative swim traces of each group in the fifth training trial. (C) Escape latency and (D) swimming speed in each training trial were also analyzed. (E) The time spent in the target quadrant in the probe task. (F) The number of times crossing the platform in the probe task. (G) The total distance traveled in the open field test after the probe task. (H) The expression of BDNF, NGF and NT-3 protein in hippocampus in the sham and Aβ1–42 aggregate-treated rats. n = 8 each group. * P < 0.05 and ** P < 0.01 compared with sham controls.