Table 3. EC50 values for toxicity parameters.
| Time | EC50 (uM) | P value | ||||||
|---|---|---|---|---|---|---|---|---|
| M | 4F | 3F | M vs 3F vs 4F | 3F vs 4F | M vs 4F | M vs 3F | ||
| Diclofenac | Ca 5h | 4.12 | 6.04 | 37.57 | 0.2105 | 0.6568 | 0.9507 | 0.1142 |
| ER 4h | 227.70 | 1031 | 250.90 | 0.0251 | 0.0134 | 0.1192 | 0.8834 | |
| TOTO3 3h | 28.76 | 67.43 | 74.81 | 0.7071 | 0.9206 | 0.4603 | 0.4326 | |
| TMRE 3h | 839.90 | 542.70 | 716.90 | 0.0061 | 0.0399 | 0.0020 | 0.1755 | |
| ROS 3h | 431.60 | 83554 | 1762 | < 0.0001 | 0.3029 | < 0.0001 | 0.0003 | |
| ER 2h | 59.24 | 339.30 | 597.90 | < 0.0001 | 0.4995 | < 0.0001 | 0.0030 | |
| TOTO3 1h | 1056 | 1559 | 1511 | 0.8923 | 0.9946 | 0.9083 | 0.6617 | |
| TMRE 1h | 1430 | 1597 | 1465 | 0.7430 | 0.6169 | 0.4572 | 0.8697 | |
| ROS 30 min | 1182 | 1628 | 1175 | 0.0004 | 0.0002 | 0.0077 | 0.9579 | |
| Chlorpromazine | Ca 5h | - | - | - | - | - | - | - |
| ER 4h | 4.43 | 9.38 | 8.06 | 0.0031 | 0.5677 | 0.0017 | 0.0346 | |
| TOTO3 3h | 186.30 | 141 | 164.30 | 0.0124 | 0.0610 | 0.0082 | 0.1597 | |
| TMRE 3h | 36.12 | 22.82 | 56.12 | 0.0395 | 0.0127 | 0.2471 | 0.0395 | |
| ROS 3h | - | - | - | - | - | - | - | |
| ER 2h | 5.90 | 16.93 | 8.07 | 0.0217 | 0.0842 | 0.0067 | 0.4305 | |
| TOTO3 1h | 495.50 | 61.98 | 1333 | 0.0089 | 0.0045 | 0.074 | 0.7624 | |
| TMRE 1h | 90.23 | 79.76 | 237.20 | 0.2801 | 0.2322 | 0.8799 | 0.1879 | |
| ROS 30 min | 1.42 | 0.12 | 0.32 | 0.5681 | 0.7186 | 0.3023 | 0.5094 | |
| Acetaminophen | Ca 5h | 0.76 | 0.65 | 0.77 | 0.9968 | 0.9503 | 0.9381 | 0.9859 |
| ER 5h | 0.72 | 387.90 | 63.27 | < 0.0001 | 0.5111 | 0.0001 | < 0.0001 | |
| TOTO3 4h | 0.54 | 1.34 | 1.39 | 0.0002 | 0.8973 | 0.0018 | 0.0020 | |
| TMRE 4h | 10.80 | 2.12 | 26.92 | < 0.0001 | < 0.0001 | 0.0001 | 0.0632 | |
| ROS 3h | 0.71 | 0.70 | 3.44 | 0.8314 | 0.529 | 0.9903 | 0.6924 | |
| ER 2h | 17.59 | 26.92 | 28.16 | 0.3134 | 0.9244 | 0.2694 | 0.114 | |
| TOTO3 1h | 13.72 | 167.80 | 19.20 | 0.0205 | 0.0601 | 0.005 | 0.5354 | |
| TMRE 1h | 2.64 | 1.37 | 3.88 | 0.0475 | 0.0092 | 0.0824 | 0.3416 | |
| ROS 30 min | 46.67 | 25.15 | 22.36 | 0.0474 | 0.6031 | 0.0328 | 0.1283 | |
| Verapamil | Ca 6h | - | - | - | - | - | - | - |
| ER 5h | - | - | - | - | - | - | - | |
| TOTO3 5h | 617.20 | 425.30 | 681 | 0.2581 | 0.1268 | 0.1268 | 0.7627 | |
| TMRE 5h | 223.90 | 104.40 | 181.10 | 0.0005 | 0.0013 | 0.0048 | 0.0045 | |
| ROS 4h | - | - | - | - | - | - | - | |
| ER 3h | - | - | - | - | - | - | - | |
| TOTO3 2h | 1252 | 936.90 | 667.10 | 0.0292 | 0.0314 | 0.3175 | 0.0117 | |
| TMRE 2h | 555.80 | 611.60 | 557.50 | 0.9045 | 0.4088 | 0.7712 | 0.9965 | |
| ROS 30 min | 859.30 | 1518 | 1738 | 0.0040 | 0.7594 | 0.0021 | ||
| Omeprazole | Ca 5h | 9.41 | 45.57 | 56.77 | 0.2160 | 0.8578 | 0.1725 | 0.2187 |
| ER 4h | 754.60 | 186.90 | 185.40 | 0.1681 | 0.9732 | 0.1397 | 0.0771 | |
| TOTO3 3h | 3855 | 695 | 539.10 | 0.6500 | 0.8649 | 0.5460 | 0.3027 | |
| TMRE 3h | 356.20 | 343.40 | 490.10 | 0.9464 | 0.8233 | 0.9789 | 0.7693 | |
| ROS 3h | 0.29 | 0.23 | 0.67 | 0.9279 | 0.8559 | 0.9635 | 0.6711 | |
| ER 2h | 140.70 | 245.50 | 148.90 | 0.1889 | 0.4453 | 0.0445 | 0.9164 | |
| TMRE 1h | 16.40 | 19.07 | 178.60 | 0.4699 | 0.2915 | 0.8590 | 0.2200 | |
| TOTO3 1h | - | - | - | - | - | - | - | |
| ROS 30 min | - | - | - | - | - | - | - | |
P value< 0.05 are reported in bold and italic.
-: EC50 value could not be calculated.