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. 2015 Apr 7;10(4):e0120709. doi: 10.1371/journal.pone.0120709

Fig 6. Benfotiamine acts synergistically with cytarabine to inhibit leukemia cell proliferation.

Fig 6

BM-S blasts (A) and HL-60 cells (B) were cultured for 72 hours with various concentrations of cytarabine (Ara-C) alone or in combination with benfotiamine (50 μM) and the degree of cell viability was assessed using an MTT assay. THP-1 cells (C), OUN-1 cells (D) and AML-2 blasts (E) were cultured for 72 hours with Ara-C alone (THP-1, 10 nM; OUN-1 and AML-2, 50 nM) or in combination with the indicated doses of benfotiamine and the degree of cell viability was assessed using an MTT assay. The combination index (CI) was calculated to determine drug interactions using the CompuSyn software program.