Table3.
Cognitive ability and adaptive function across study groups.
| PTEN-ASD | Macro-ASD | Normo-ASD | Healthy Controls | 4-Group Comparison |
PTEN-ASD vs. Macro-ASD |
||
|---|---|---|---|---|---|---|---|
| M (SD) | M (SD) | M (SD) | M (SD) | Wald Χ2 (p) | Cohen’s d | ||
| Full Scale IQ | 75.9 (21.4) | 95.8 (25.7) | 90.9 (21.9) | 108.4 (14.2) | 29.15 | (<.001) | .93 |
| Verbal IQ | 75.3 (24.3) | 93.0 (23.7) | 91.0 (23.1) | 105.9 (14.6) | 16.86 | (.001) | .84 |
| Non-Verbal IQ | 78.1 (17.7) | 95.9 (24.4) | 92.3 (21.3) | 108.7 (15.2) | 30.23 | (<.001) | .90 |
| Processing Speed | 76.9 (23.9) | 99.7 (18.9) | 92.5 (22.2) | 104.1 (10.3) | 17.27 | (.001) | 1.15 |
| Working Memory | 70.6 (15.3) | 90.2 (19.9) | 87.8 (20.0) | 107.8 (10.5) | 52.34 | (<.001) | 1.07 |
| Auditory Immediate Memory | 74.0 (13.9) | 93.7 (24.7) | 86.3 (19.0) | 105.8 (17.3) | 28.69 | (<.001) | .96 |
| Visual Immediate Memory | 77.9 (13.2) | 91.0 (22.5) | 79.5 (17.8) | 95.8 (15.4) | 12.94 | (.005) | .69 |
| SIB-R Broad Independence | 50.4 (23.7) | 66.8 (23.9) | 59.9 (23.5) | 109.1 (29.0) | 61.85 | (<.001) | .85 |
| Motor | 60.1 (29.2) | 79.3 (20.5) | 73.7 (26.8) | 111.7 (27.0) | 32.56 | (<.001) | .87 |
| Social Interaction/Communication | 51.9 (30.9) | 70.8 (31.7) | 67.3 (26.6) | 115.4 (13.2) | 97.57 | (<.001) | .75 |
| Personal Living | 53.4 (20.6) | 60.7 (21.8) | 65.8 (19.6) | 102.6 (19.8) | 49.09 | (<.001) | .49 |
| Community Living | 54.5 (24.2) | 71.7 (21.4) | 62.3 (23.7) | 97.6 (23.1) | 29.53 | (<.001) | .94 |
Note: Bold indicates a significant a priori contrast (p<.05) between PTEN-ASD and Macro-ASD. Wald Χ2 from GEE models evaluates differences between all patient groups using 3 degrees of freedom.