Table 4.
Unadjusted data (means ± standard errors) are shown for all volumetric and cellular measures, sorted by gender, depression duration, and suicide.
| Control: | Volume (mm3) | Neuron number (106) | Neuron densitya (103) | Glia number (106) | Glia densitya (103) | Glia to neuron ratiob | NV cell number (106) | NV cell densitya (103) |
|---|---|---|---|---|---|---|---|---|
| LAN: | ||||||||
| Male | 310±19.3 | 5.73±.40 | 17.94±.98 | 27.05±1.85 | 85.01±5.53 | 4.75±.21 | 4.48±.59 | 13.94±1.57 |
| Female | 253±23.4 | 5.55±.65 | 22.12±.96 | 24.19±2.08 | 97.73±4.71 | 4.43±.25 | 2.43±.36 | 9.61±.62 |
| All | 288±16.9 | 5.66±.33 | 19.61±.95 | 25.91±1.39 | 90.10±4.18 | 4.62±.16 | 3.66±.49 | 12.21 ±1.17 |
| BN: | ||||||||
| Male | 245±6.2 | 5.60±.25 | 23.36±1.39 | 18.69±1.10 | 77.61±4.41 | 3.34±.13 | 2.81±.39 | 11.70±1.66 |
| Female | 192±15.1 | 4.81±.11 | 24.78±2.08 | 18.45±.86 | 94.16±4.37 | 3.84±.16 | 2.42±.36 | 12.11±1.19 |
| All | 224±10.9 | 5.28±.20 | 23.93±1.13 | 18.59±.71 | 84.23±4.04 | 3.54±.13 | 2.65±.27 | 11.86±1.05 |
| ABN: | ||||||||
| Male | 104±4.0 | 1.86±.11 | 17.63±.60 | 7.38±.63 | 69.82±4.40 | 3.97±.24 | 1.28±.15 | 12.00±1.14 |
| Female | 90±4.3 | 1.56±.11 | 18.36±.73 | 6.84±.19 | 81.06±3.11 | 4.44±.25 | 1.13±.12 | 13.34±1.18 |
| All | 98±3.5 | 1.74±.09 | 17.92±.45 | 7.16±.38 | 74.32±3.33 | 4.16±.18 | 1.22±.10 | 12.54±.82 |
| TOTAL: | ||||||||
| Male | 659±19.9 | 13.19±.50 | 53.12±2.27 | 3.97±.14 | 8.56±.80 | |||
| Female | 535±41.5 | 11.92±.57 | 49.49±2.59 | 4.20±.10 | 5.98±.62 | |||
| All | 610±27.7 | 12.68±.41 | 51.67±1.72 | 4.06±.10 | 7.53±.66 | |||
| MDD:
| ||||||||
| LAN: | ||||||||
| Male | 330±20.8 | 6.07±.51 | 19.81±.42 | 30.52±2.72 | 99.81±4.08 | 5.03±.16 | 4.85±.59 | 16.17±2.25 |
| Female | 313±12.6 | 5.59±.18 | 18.47±.75 | 26.93±1.92 | 88.19±4.02 | 4.79±.21 | 3.90±.37 | 12.77±.95 |
| ≤5 Yrs | 353±19.7 | 6.46±.58 | 19.54±.91 | 32.05±3.47 | 97.23±8.10 | 4.95±.22 | 5.41±.65 | 17.03±3.14 |
| > 5 Yrs | 302±12.0 | 5.47±.23 | 18.98±.47 | 26.87±1.58 | 92.71±2.10 | 4.91±.16 | 3.79±.30 | 13.08±.76 |
| Suicide | 330±19.6 | 6.20±.44 | 20.11±.44 | 30.39±2.69 | 98.27±4.53 | 4.89±.19 | 4.67±.65 | 15.43±2.46 |
| No suicide | 312±14.9 | 5.44±.31 | 18.11±.54 | 27.08±2.02 | 89.98±4.23 | 4.96±.17 | 4.11±.31 | 13.63±.64 |
| All | 322±12.4 | 5.85±.29 | 19.19±.44 | 28.86±1.72 | 94.45±3.22 | 4.92±.13 | 4.41±.37 | 14.60±1.33 |
| BN: | ||||||||
| Male | 238±9.5 | 5.18±.20 | 22.97±.98 | 20.20±1.56 | 88.02±3.09 | 3.89±.26 | 3.59±.42 | 15.66±1.43 |
| Female | 222±12.4 | 4.77±.53 | 22.33±1.72 | 16.97±.89 | 80.56±5.53 | 3.66±.27 | 2.48±.23 | 11.72±1.12 |
| ≤5 Yrs | 250±5.2 | 5.05±.34 | 21.29±1.42 | 20.73±2.09 | 86.56±6.17 | 4.10±.29 | 3.45±.51 | 14.29±1.56 |
| > 5 Yrs | 218±9.9 | 4.99±.36 | 23.72±1.02 | 17.51±.86 | 83.74±3.05 | 3.58±.22 | 2.90±.37 | 13.82±1.60 |
| Suicide | 236±13.3 | 5.35±.37 | 23.39±1.36 | 20.84±1.45 | 90.58±3.02 | 3.96±.31 | 3.18±.50 | 13.48±1.48 |
| No suicide | 226±8.2 | 4.67±.28 | 22.02±1.15 | 16.87±1.13 | 79.25±4.15 | 3.63±.20 | 3.08±.38 | 14.55±1.70 |
| All | 231±7.6 | 5.01±.24 | 22.71±.87 | 18.85±1.06 | 84.91±2.98 | 3.79±.18 | 3.13±.30 | 14.02±1.09 |
| ABN: | ||||||||
| Male | 106±6.7 | 1.69±.12 | 16.76±.66 | 7.80±.62 | 76.68±2.83 | 4.60±.18 | 1.71±.22 | 16.57±1.56 |
| Female | 101±7.2 | 1.67±.08 | 17.53±.99 | 6.87±.33 | 72.43±5.29 | 4.13±.21 | 1.31±.11 | 13.92±1.68 |
| ≤5 Yrs | 108±5.5 | 1.72±.13 | 16.66±1.04 | 7.77±.68 | 75.42±5.91 | 4.53±.26 | 1.58±.10 | 15.32±.95 |
| > 5 Yrs | 101±7.3 | 1.66±.09 | 17.37±.63 | 7.15±.49 | 74.54±2.42 | 4.31±.18 | 1.52±.24 | 15.57±1.96 |
| Suicide | 101±3.1 | 1.71±.12 | 17.24±.70 | 7.89±.48 | 79.81±2.73 | 4.65±.18 | 1.55±.12 | 15.82±1.34 |
| No suicide | 107±9.3 | 1.66±.10 | 16.91±.91 | 6.93±.61 | 70.00±3.81 | 4.15±.19 | 1.53±.28 | 15.11±2.03 |
| All | 104±4.7 | 1.68±.08 | 17.07±.55 | 7.41±.40 | 74.91±2.68 | 4.40±.15 | 1.54±.14 | 15.47±1.17 |
| TOTAL: | ||||||||
| Male | 674±28.5 | 12.94±.62 | 58.52±4.33 | 4.49±.17 | 10.14 ±.83 | |||
| Female | 635±29.3 | 12.03±.57 | 50.90±2.85 | 4.17±.21 | 7.69 ±.50 | |||
| ≤5 Yrs | 711±21.9 | 13.23±.89 | 60.56±5.87 | 4.52±23 | 10.44 ±1.12 | |||
| > 5 Yrs | 619±22.5 | 12.09±.37 | 51.61±2.15 | 4.24±.17 | 8.18 ±.53 | |||
| Suicide | 670±36.1 | 13.35±.70 | 59.81±4.55 | 4.48±.23 | 9.52±1.23 | |||
| No suicide | 646±22.4 | 11.78±.33 | 50.88±2.93 | 4.23±.15 | 8.72±.37 | |||
| All | 658±20.6 | 12.56±.44 | 55.34±2.91 | 4.36±.14 | 9.12 ±.63 | |||
Note that statistical analyses were performed on adjusted means; see text for statistically significant differences among groups. Volumetric calculations were performed on post-processing tissue dimensions without correction for shrinkage; cell numbers were calculated with the optical fractionator, which generates estimates that are independent of shrinkage (West et al. 1991).
Density values reflect cells/mm3.
Glia to neuron ratio was lowest in the BN, which contains a large proportion of the paralaminar nucleus, containing densely packed neurons.
ABN, accessory basal nucleus; BN, basal nucleus; LAN, lateral nucleus; NV cell, neurovascular cell.
TOTAL refers to the basolateral amygdala as a whole. ≤5 Yrs, depression duration of five years or fewer; > 5 Yrs, depression duration of more than five years.