Table 3. Association between radiological features, markers of cellular proliferation, and early mortality in patients with newly diagnosed anaplastic astrocytic tumours.
| IDH1-R132H positive patients | IDH1-R132H negative patients | |||
|---|---|---|---|---|
| Number of events | p-value | Number of events | p-value | |
| Tumour location | NS | NS | ||
| Frontal lobe | 2/10 | 1/3 | ||
| Non-frontal lobe | 1/8 | 8/15 | ||
| Degree of enhancement | NS | NS | ||
| Less than choroid plexus | 0/8 | 2/7 | ||
| Equal to or greater than choroidplexus | 3/10 | 7/11 | ||
| Heterogeneity of enhancement | NS | NS | ||
| None/homogeneous | 1/7 | 2/4 | ||
| Heterogeneous | 2/11 | 7/14 | ||
| Volume of contrast-enhancing tumour | 0.007 | NS | ||
| < 5 cm3 | 0/12 | 6/12 | ||
| ≥ 5 cm3 | 3/6 | 3/6 | ||
| Peri-tumoural edema | NS | 0.046 | ||
| < 1 cm beyond tumour | 1/13 | 4/12 | ||
| ≥ 1 cm beyond tumour margin | 2/5 | 5/6 | ||
| Mass effect | NS | NS | ||
| None/mild | 2/12 | 4/13 | ||
| Moderate/severe | 1/6 | 5/6 | ||
| Intra-tumoural hemorrhage | NS | NS | ||
| Present | 0/2 | 1/2 | ||
| Absent | 3/16 | 8/16 | ||
| Cyst formation | NS | NS | ||
| Present | 0/3 | 0/1 | ||
| Absent | 3/15 | 9/17 | ||
| Tumour margin | NS | NS | ||
| Irregular | 2/8 | 5/8 | ||
| Smooth | 1/10 | 4/10 | ||
| Min apparent diffusion coefficient | NS | NS | ||
| < 0.950 x 10-3 mm2/sec | 2/5 | 4/11 | ||
| ≥ 0.950 x 10-3 mm2/sec | 1/13 | 5/7 | ||
| Mitoses | NS | 0.009 | ||
| < 5 / mm2 | 1/11 | 8/11 | ||
| ≥ 5 / mm2 | 2/7 | 1/8 | ||
| Ki67 labelling index | NS | NS | ||
| < 10 | 0/8 | 3/4 | ||
| ≥ 10 | 3/10 | 6/15 | ||
Events are deaths occurring within 12 months of the original diagnosis.
Abbreviations: NS = not significant.