Table 3.

The number of interactions for 14 out of 38 transcription factors changed dramatically from normal to metastasis stage (fold change >2)

Gene name	Normal	Adjacent	Tumor	Metastasis	Fold change
HOXB13	143	176	43	52	2.75
ZEB1	135	137	74	33	4.09
SIM2	120	132	115	25	4.80
TFAP2A	60	30	25	63	0.95
ZNF205	56	38	28	44	1.27
EZH2	46	24	81	81	1.76
MXD4	43	31	32	69	1.60
ZNF146	42	45	60	72	1.71
CAMTA1	41	22	21	37	1.11
MAZ	39	64	56	46	0.85
PLAGL1	26	36	39	30	0.87
HOXC6	34	53	78	47	1.38
FOS	63	49	69	65	0.97
ELK4	35	34	17	33	0.94
NKX2-2	28	33	43	30	0.93
MNX1	26	20	29	70	2.69
AR	103	61	35	48	2.15
PBX1	45	64	117	37	0.82
FOXA1	108	153	41	34	3.18
INSM1	21	26	23	32	0.66
STAT1	113	97	122	16	7.06
HLF	123	120	86	25	4.92
TCF21	59	102	58	25	2.36
ISL1	65	26	68	22	2.95
GATA3	42	34	68	22	1.91
KLF6	76	26	20	37	2.05
SMAD3	41	18	28	40	1.03
NHLH2	27	18	32	34	0.79
EGR3	32	35	40	26	1.23
FOXF1	32	151	129	26	0.81
ATF6	44	27	17	40	1.1
VDR	30	27	18	33	0.91
FOXC1	14	42	68	33	2.36
STAT2	23	32	19	34	0.68
JUNB	21	50	47	48	2.29
RARB	21	31	27	26	0.81
SNAI2	25	25	34	24	1.04
ZNF529	10	26	24	42	4.2