Table V.
Association of rs2513280 (GAL) Genotypes With Measures of Cognition in the ALSPAC cohort
| Test | Mean age (years) | N | C/C | C/G | G/G | Padd | Pdom | Prec |
|---|---|---|---|---|---|---|---|---|
| WORD | 7.5 | 5,986 | 28.060 (9.489) | 28.409 (8.847) | 28.472 (9.393) | 0.657 | 0.627 | 0.734 |
| IQ | 8.7 | 5,517 | 104.946 (18.336) | 104.109 (15.961) | 105.042 (16.508) | 0.124 | 0.914 | 0.076 |
| Nonword | 8.7 | 5,532 | 7.422 (2.360) | 7.236 (2.499) | 7.270 (2.522) | 0.813 | 0.381 | 0.981 |
| WOLD | 8.7 | 5,561 | 7.419 (2.079) | 7.391 (1.894) | 7.550 (1.981) | 0.032 | 0.455 | 0.030 |
| Count–Span score | 10.6 | 5,271 | 1.221 (0.220) | 1.179 (0.341) | 1.194 (0.320) | 0.434 | 0.292 | 0.216 |
| Count–Global score | 10.6 | 5,271 | 18.520 (7.624) | 18.315 (6.897) | 18.355 (7.566) | 0.274 | 0.927 | 0.205 |
Genotype data are presented as mean (standard deviation).
WORD, Wechsler Objective Reading Dimensions (number of correct words read (maximum of 55 words)); IQ, IQ test; Nonword, Nonword Repetition test (0–12 correct answers, children were asked to repeat 12 “nonwords”); WOLD, Listening comprehension and oral expression (0-15 correct answers); Count, Counting span working memory task; Span score (maximum score of 5 in increments of 0.5) and Global score (maximum score of 42).
Padd, P-value for addictive effect (C/C = 0, C/G = 1, G/G = 2); Pdom, P-value for dominant effect (C/C = 0, C/G= 1, G/G = 1); Prec, P-value for recessive effect (C/C = 0, C/G = 0, G/G = 1).