Table VI.

Association of rs2513280 (GAL) Genotypes With Addiction Related Traits in the ALSPAC Cohort

Phenotype	Mean age (years)	N	Case (%)	Control (%)	C/C (%)	C/G (%)	G/G (%)	OR	Padd
CAST score	17.8	406	32.3	67.6	2.2	25.6	72.2	2.070	0.007
Frequency of cannabis use	17.8	169	48.6	51.4	2.3	23.7	74.0	2.243	0.018
≥1 Day ‘Binge drinking‘	15.5	3538	8.8	91.2	2.2	26.6	71.2	1.338	0.022
Frequency of alcohol use	15.5	2272	9.1	90.9	2.2	25.0	72.8	1.286	0.124
Frequency of alcohol use	17.8	1530	49.8	50.2	2.2	25.7	72.1	1.226	0.046
Daily versus non-daily cigarette smokers	17.8	878	20.2	79.8	2.2	26.0	71.8	1.001	0.997
PGSI score	17.8	2353	8.4	91.6	2.2	25.6	72.2	1.175	0.299

Genotype data are presented as percentage.

CAST, Cannabis abuse screening test—CAST Score of 1 or more = 1, CAST Score of 0 = 0 (having still used cannabis within the last 12 months).

Frequency of cannabis use, 4+ times per week = 1, 2–3 times per week = 0.

≥1 day ‘Binge drinking‘– participants were asked whether they spent a great deal of their day drinking alcohol over the last 2 years (yes = 1, no =0).

Frequency of alcohol use—drinking 2–3 times per week = 1, monthly ≥0.

PGSI, Problem gambling severity index—Problematic gambling exhibited in the past = 1, non-problem or no gambling in the past year = 0.

P_add, P-value for addictive effect (C/C = 0, C/G = 1, G/G = 2).