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. 2015 Apr 8;35(14):5781–5791. doi: 10.1523/JNEUROSCI.1238-14.2015

Figure 5.

Figure 5.

Genetic deletion of nNOS blocks cortically evoked spike activity elicited by PDE10 inhibitor administration: within-subjects studies. A, Spike probability was titrated to ∼50% by the experimenter, and no differences in the probability of responses evoked by cortical stimulation were observed between WT and nNOS KO mice, indicating that currents were titrated accurately across groups (p > 0.05; t test). B, Striatal MSNs recorded in nNOS KO mice exhibited decreased responsiveness to cortical stimulation. Thus, an increase in the current intensity required to elicit spike activity ∼50% of the time was observed in nNOS KO mice. *p < 0.05 (t test). C, Pairwise comparisons revealed that TP-10 administration induced a facilitatory effect on cortically evoked spike activity in the WT group as significant reductions in current intensity required to evoke spike activity 50% of the time were observed 40–60 min after drug (#p < 0.05; **p < 0.01 compared with 10–20 min postdrug measures; two-way ANOVA, Tukey post hoc test). In nNOS KO mice, TP-10 did not change the current intensity required to evoke spike activity 50% of the time (p > 0.05, two-way repeated-measures ANOVA). Results are derived from n = 6 cells/6 mice per group.