Table 2.
Gene | Name | Chromosome | Pathway | Other diseases | References |
---|---|---|---|---|---|
IL23A | IL23 p19 | 12q13 | IL23 | [42] | |
IL12B | IL12/IL23 p40 | 5q33 | IL23 | IBD, PsA, AS, MS | [42, 53, 84–86] |
IL23R | IL23R | 1p31 | IL23 | IBD, PsA, AS | [42, 53, 87, 88] |
TYK2 | Tyrosine kinase 2 | 19p13 | IL23 | IBD, SLE, MS? | [89–92] |
TRAF3IP2 | TNF receptor-associated factor 3 interacting protein 2 | 6q21 | NFKB, IL17 | PsA, RA, CD | [92–96] |
TNFA IP3 | TNFα-induced protein3 | 6q23 | NFKB | PsA, SLE, RA, CD | [42, 95, 97, 98] |
TNIP1 | TNFAIP3-interacting protein 1 | 5q33 | NFKB | PsA, SLE, SSc | [42, 99, 100] |
DEFB4 | Defensin β 4 | 16q12 | IL17 | [101] |
IBD inflammatory bowel disease, PsA psoriatic arthritis, AS ankylosing spondylitis, MS multiple sclerosis, CD celiac disease, RA rheumatoid arthritis, SLE systemic lupus erythematous, SSc systemic sclerosis