Mean HRQoL scores at baseline, 3 and 6 months by caseness for depression (based on HADS-D score at baseline: score ≥8 = case; score <8 = noncase). SF-36 MCS and PCS scores were normalized to a mean of 50 (SD 10). The solid line represents the SF-36 general US population norm (mean 50) and the dotted line represents the clinical depression norms (MCS mean 34.8; PCS mean 45.0) [25]. Mean EQ-5D HSI scores were converted from a 0–1 scale to a 0–100 scale. The solid line represents the UK general population norms (EQ-5D VAS mean 82.5; EQ-5D HSI mean 86) [26]. EQ-5D European Quality of Life-5 Dimensions, HADS-D Hospital Anxiety and Depression Scale-depression, HSI health status index, HRQoL health-related quality of life, MCS mental component summary, PCS physical component summary, SD standard deviation, SF-36 Short Form 36 Health Status Survey, VAS visual analog scale