Table 3.
Tumor-associated antigens identified from patients with HCC and their functions
| Intracellular component | Autoantigens | Biological functions |
|---|---|---|
| Nucleus | DNA topoisomerase II | DNA replication/transcription |
| CENP-F | Mitotic function | |
| HCC-1 | mRNA splicing | |
| Cyclin B1 | Cell-cycle progression | |
| Fibrillarin | rRNA processing | |
| NOR-90/hUBF | RNA pol I transcription | |
| B23 | Ribosome maturation | |
| Ku86 | DNA doule-strand break repair | |
| Cytoplasm | p62/IMP2 | Regulation of IGF-II mRNA |
| Koc/IMP3 | Regulation of IGF-II mRNA | |
| Golgi | Processing, transporting and sorting of intracellular proteins |