Table 4.
Autoantibodies to stress proteins in liver disease
| Autoantibodies | Molecular target | Associated liver disease | Clinical significance |
|---|---|---|---|
| Anti-ox-LDL | ox-LDL | HCV | Correlation with hepatic steatosis |
| Anti-MDA | MDA | HCV, NASH | Correlation with hepatic steatosis |
| Anti-CYP2E1 | CYP2E1 | Type 1 AIH, HCV, alcohol, halothane-induced hepatitis | |
| Anti-cardiolipin | Cardiolipin | Type 1 AIH, PBC, NASH, alcohol, HCV | IgG4 type of anti-CYP2E1 correlation with hepatic fibrosis |
| HCV | |||
| Anti-SOD | SOD | AIH, HCV | Correlation with anti-HSP65 |
| Anti-HSP | HSP65 | AIH | |
| HSP70 | HCV | Inverse correlation with disease-activity |