Table 4.
Demographic and bone mineral determinants of MCD in pediatric HD patients
| Linear regression matrix |
Multiple regression |
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|---|---|---|---|---|---|---|---|---|---|---|
| Pearson r |
MCD = 28 − 0.01 (iPTH) − 6.1 (AA race) + 6.1 (glomerular disease) |
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| Parameter | MCD | Female | AA race | Glomerular disease | iPTH | 25(OH) VitD | B-coefficient | β-coefficient | P value | 95% confidence interval |
| MCD (n/mm2) | 1.00 | 28.3 | − | <0.001* | 21.3 → 35.3 | |||||
| Female | +0.46* | 1.00 | ||||||||
| AA race | −0.50* | −0.19 | 1.00 | −6.07 | −0.46 | 0.01* | −10.5 → −1.7 | |||
| Glomerular disease | +0.59* | +0.39* | −0.15 | 1.00 | +6.06 | +0.44 | 0.02* | +1.3 → +10.8 | ||
| iPTH (pg/mL) | −0.42* | +0.03 | −0.09 | −0.24 | 1.00 | −0.01 | −0.36 | 0.03* | −0.01 → −0.000 | |
| 25 (OH)D (ng/mL) | +0.53* | +0.06 | −0.33 | +0.41* | −0.44* | 1.00 | ||||
| Mean ± SD | 24.0 ± 7 | 9/19 (47%) | 13/19 (68%) | 14/19 (74%) | 426 ± 265 | 34 ± 16 | F = 5.9 | 0.001* | R2 = 64.2% | |
Linear and multiple regression analysis.
MCD, maximal capillary density [capillaries (n)/square millimeter (mm2)]; iPTH, intact parathyroid hormone; AA, African American; 25(OH)VitD, 25 hydroxy vitamin D level.
*Significance <0.05.
Mean ± SD or number/total patients with percent (%) is given for all parameters in the units specified.
R2 of the multivariate model explains 64.2% of the variance; P = 0.001. B is the ‘unstandardized coefficient’, which denotes the change in MCD (n/mm2) for every 1 unit increment in the specified parameter. The standardized β (beta) coefficient reflects the strength of the effect change of a given parameter on MCD relative to all other independent parameters in the model.