Skip to main content
. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Trauma Acute Care Surg. 2015 Apr;78(4):671–686. doi: 10.1097/TA.0000000000000568

Figure 1.

Figure 1

Clinical paradigm for Multiple Organ Dysfunction (MOD). Patients initially present with SIRS during resuscitation and an early MOD syndrome with the potential for an early death. A compensatory period of CARS follows for those patients who survive the early inflammatory insult, but they are subject to a later “second hit” from a nosocomial infection, endotoxemia, or the persistence of devitalized tissue. A late, more severe MOD syndrome can develop with a higher risk of death. Substantial contributions to illustrate this concept came from Ron Maier and Linc Moldawer.