Fig. 3.

Short-term UE2316 treatment reversibly improves spatial memory in aged C57BL/6J mice. (A) All aged mice were tested in the immediate version of the Y-maze (1 min inter-trial interval (ITI)) confirming preferential exploration of the novel arm and no visual problems identifying cues around the maze. (B) UE2316 improved spatial memory (more time spent in novel arm) on the 10th day of treatment while vehicle treated aged mice remained impaired in the Y-maze (n = 8–9/group). (C) Improved spatial memory in UE2316 treated mice reversed after swapping to vehicle, while impaired spatial memory in vehicle-treated mice improved after swapping to UE2316. Results represent mean ± SEM. ***P < 0.0001, §P < 0.01 and ♯P < 0.05 vs. other arms. *P < 0.05 vs corresponding treatment.