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. 2015 Apr 8;9:112. doi: 10.3389/fnins.2015.00112

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Copyright © 2015 Carpenter, Jalloh and Hutchinson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationships in TBI brain for glycolytic lactate and pentose phosphate pathway (PPP)-derived lactate vs. PbtO₂. Concentrations of glycolytic 2,3-¹³C₂ lactate (upper panel) and PPP-derived 3-¹³C lactate (middle panel) plotted vs. PbtO₂. Lower panel: ratio (%) of PPP-derived 3-¹³C lactate to glycolytic 2,3-¹³C₂ lactate, plotted vs. PbtO₂. Each data point represents the results of NMR analysis of the combined contents of 24 × 1 h of microdialysate collection vials from one microdialysis catheter, plotted against the corresponding PbtO₂ concentration expressed in mmHg, measured using a Licox oxygen probe placed alongside the microdialysis catheter in the brain. Lines are fitted by linear regression (statistics shown are Pearson's correlation coefficient r and analysis of variance P–value). Data are from 13 TBI patients. Four of these thirteen had a second period of monitoring, making 17 data points in total for each correlation. Originally published by Jalloh et al. (2015) in J Cereb Blood Flow Metab 35: 111–120, and reproduced with permission of Nature Publishing Group.