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. 2015 Apr 8;9:123. doi: 10.3389/fncel.2015.00123

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Copyright © 2015 Magistretti, Spaiardi, Johnson and Masetto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A model for phase-locking based on the properties of elementary Ca²⁺ currents. (A) the combined effects of the decrease in first latency and the decrease of elementary Ca²⁺-current amplitude brought about by IHC depolarization, resulting in a hypothetical “threshold” Ca²⁺ concentration for exocytotic Ca²⁺-sensor saturation (blue horizontal dashed line) being reached with similar timing as for a lower depolarization. This model would only work if vesicle release is governed by a single Ca²⁺ channel coupled in a nanodomain to the vesicle/Ca²⁺ sensor. (B) During high-frequency stimuli (e.g., 1 KHz), signal transmission likely depends upon elementary tail current (asterisks), particularly for high-intensity stimuli where the elementary current would be minimized by the smaller I_Ca driving force.