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. 2015 Mar 25;12:23. doi: 10.1186/s12950-015-0068-1

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© Shi et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Chronic intermittent hypobaric hypoxia pretreatment improves body weight, paw thickness and Arthritic Index in collagen-induced arthritis rat. Chrinic intermittent hypobaric hypoxia (CIHH) pretreatment antagonized the decrease of body weight (A) and the increase of paw thickness (B), and decreased the Arthritic Index (C) in collagen-induced arthritis rat. AI: arthritis index; CIA: collagen-induced arthritis group; CIHH+CIA: CIHH treated CIA group; Data were expressed as mean ± SEM, n = 6 for each group, *p<0.05 vs CIA, #p<0.05 vs control.