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. 2015 Mar 20;16(1):42. doi: 10.1186/s12931-015-0200-z

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© Schilter et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Inhibition of inflammation during CLP induces sepsis. Cecal ligation and puncture (CLP) was induced by ligating and perforating the cecum. Cecal contents were expressed through the perforation. The cecum was placed back into the peritoneal cavity and the peritoneal wall and skin incisions were then closed. 6 hours after surgery (A) total cells (B) and neutrophils were analysed in the peritoneal lavage. Inhibition of inflammation by VAP-1/SSAO regulation was seen in the bronchoalveolar lavage, by a decrease in (C) total cell counts, (D) neutrophils and (E) MPO. Treatment with PXS-4728A increased survival (F). N = 4-6 per group for the BALF, peritoneal lavage and MPO; N = 8/10 per group for survival; **p < 0.01, ***p < 0.001 over sham.