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. 2015 Mar 20;16(1):42. doi: 10.1186/s12931-015-0200-z

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© Schilter et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Inhibition of inflammation during viral induced asthma exacerbation. Allergic airways disease was established with house dust mite (HDM) sensitization followed by HDM challenge. RV1b infection was superimposed on the allergic mice to induce an exacerbation and results analysed 24 hours post infection. PXS-4728A reduced (A) total BALF neutrophils and (B) significantly reduced airways hyperreactivity to methacholine challenge in ventilated mice as of 2.5 mg.ml⁻¹. N = 8 per group for AHR and N = 4 per group for BALF; ***p < 0.001 over HDM/vehicle/RV. AHR analysed by two-way ANOVA with Newman-Keuls Multiple Comparison Test.