Table 1.
Activity and selectivity of PXS-4728A in vitro
| Assay | IC 50 | |
| Recombinant human VAP-1/SSAO (AOC3) | 5 nM | |
| Gonadal fat tissue homogenate; mouse, rat, dog, rabbit | <10 nM | |
| Assay | IC 50 | Selectivity |
| Recombinant diamine oxidase (AOC1) | 12.0 μM | >2000x |
| Recombinant retina specific amine oxidase (AOC2) | 2.76 μM | >500x |
| Purified lysyl oxidase from lung fibroblasts | 13.2 μM | >2000x |
| Recombinant lysyl oxidase like 2 | 10.4 μM | >2000x |
| Recombinant monoamine oxidase A | >100 μM | >2000x |
| Recombinant monoamine oxidase B | 2.7 μM | >500x |
| Recombinant lysine demethylase | >10 μM | >2000x |