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Pharmacokinetic profile of PXS-4728A in rodents
| Rat | Mouse | |
|---|---|---|
| Oral dose | 6 mg.kg −1 | 10 mg.kg −1 |
| Bioavailability (%) | 55 | 92 |
| Apparent concentration at curve maximum Cmax (μg.ml−1) | 0.72 | 1.38 |
| Time of maximal concentration Tmax (hour) | 0.83 | 0.25 |
| Clearance CL (ml.kg.min−1) | 45 | 98 |
| Intravenous dose | 3 mg.kg −1 | 5 mg.kg −1 |
| Apparent concentration at curve maximum Cmax (μg.ml−1) | 4.21 | 1.6 |
| Time of maximal concentration Tmax (min) | 0.03 | 0.03 |
| Clearance CL (ml.kg.min−1) | 23 | 80 |
| Apparent half-life, t1/2 (h) | 1.1 | 0.6 |
