Table 1. Echocardiographic and hemodynamic parameters in TG mice with cardiac-specific overexpression of SLN.
| 10 weeks
|
8 months
|
|||
|---|---|---|---|---|
| Parameters | wt (n = 9) | NF-SLN TG (n = 5) | wt (n = 11) | NF-SLN TG (n = 5) |
| H/BW, mg/g | 3.93 ± 0.11 | 4.51 ± 0.14* | 4.1 ± 0.1 | 4.1 ± 0.16 |
| H/TL, mg/cm | 6.1 ± 0.14 | 7.1 ± 0.3† | 7.5 ± 0.53 | 7.6 ± 0.15 |
| HR, bpm | 572 ± 8 | 568 ± 6 | 542 ± 13.1 | 529 ± 19.9 |
| AW, mm | 0.711 ± 0.008 | 0.721 ± 0.007 | 0.77 ± 0.012 | 0.83 ± 0.03 |
| PW, mm | 0.717 ± 0.007 | 0.724 ± 0.009 | 0.78 ± 0.012 | 0.83 ± 0.024 |
| LVEDD, mm | 4.21 ± 0.04 | 4.2 ± 0.06 | 4.46 ± 0.03 | 4.57 ± 0.027† |
| LVESD, mm | 1.98 ± 0.03 | 2.43 ± 0.05* | 2.051 ± 0.05 | 2.67 ± 0.115* |
| FS, % | 52.9 ± 1.1 | 42.1 ± 0.9* | 53.9 ± 0.93 | 41.66 ± 2.36* |
| ETc, ms | 48.7 ± 1.0 | 52.5 ± 1.3† | 49.33 ± 1.163 | 51.274 ± 1.61 |
| VCFc, circ/s | 10.86 ± 0.19 | 7.98 ± 0.11* | 10.98 ± 0.293 | 8.12 ± 0.35* |
| PAVc, cm/s | 112 ± 2.7 | 96 ± 2.4* | 116.11 ± 4.8 | 90.498 ± 6.23† |
| E-wave, cm/s | 86.7 ± 1.8 | 70.5 ± 1.5* | 81.79 ± 3.0 | 68.5 ± 3.0† |
| LVESP, mmHg | 120.13 ± 5.91 | 117.87 ± 4.2 | 120.13 ± 5.23 | 122.96 ± 2.79 |
| LVEDP, mmHg | 4.6 ± 2.2 | 6.25 ± 2.1 | 4.4 ± 1.17 | 5.2 ± 1.5 |
| +dP/dTmax, mmHg/s | 10,156.12 ± 487.1 | 8,182.4 ± 487.13† | 9,181.6 ± 740.4 | 6,605.5 ± 834.8‡ |
| —dP/dTmax, mmHg/s | 9,527.022 ± 350.9 | 8,330.589 ± 349.6† | 9,052.5 ± 655.54 | 7,526.6 ± 1044.9 |
Values are mean ± SEM. HR, heart rate measured in beats per minute (bpm); H/BW, heart/body weight ratio; H/TL, heart/tibial length ratio; AW and PW, anterior and posterior (respectively) wall thickness (LV); LVEDD and LVESD; LV end diastolic and systolic dimension, respectively; FS, fractional shortening calculated as (LVEDD — LVESD)/LVEDD × 100% ETc, ejection time corrected for HR; VCFc, velocity of circumferential shortening corrected for HR = FS/ETc measured in circumferences (circ.) per second; PAVc, peak aortic velocity corrected for HR; E-wave, early-filling transmittal diastolic wave; LVESP and LVEDP, LV end systolic and diastolic pressure, respectively, measured in mmHg (1 mmHg = 133 Pa); +dP/dtmax, maximum positive first derivative of the LV pressure; —dP/dtmax, maximum negative first derivative of the LV pressure. *, P < 0.01 compared with controls. †, P < 0.05 compared with controls. ‡, P = 0.054.