Table 2.
Main effects of 31 common variants in PCSK9 on blood pressure in GWAS*.
| # | Common SNPs | Location chromosome 1 | A1+/A2 | MAF | HWE P-value | β | SE | P-value |
|---|---|---|---|---|---|---|---|---|
| 1 | rs1603717_A | 55733832 | A/G | 0.3 | 0.3 | |||
| DBP | 0.6 | 0.5 | 0.3 | |||||
| SBP | −0.3 | 0.98 | 0.8 | |||||
| 2 | rs12048828_C | 55735734 | C/T | 0.08 | 0.6 | |||
| DBP | 1.8 | 0.93 | 0.05 | |||||
| SBP | 0.5 | 1.7 | 0.8 | |||||
| 3 | rs6698904_T | 55737077 | T/C | 0.03 | 0.6 | |||
| DBP | −0.8 | 1.5 | 0.6 | |||||
| SBP | −1.4 | 2.8 | 0.6 | |||||
| 4 | rs6588553_C | 55737455 | C/T | 0.2 | 0.1 | |||
| DBP | −0.6 | 0.6 | 0.3 | |||||
| SBP | −1.5 | 1.1 | 0.2 | |||||
| 5 | rs10443235_C | 55738353 | C/T | 0.4 | 0.6 | |||
| DBP | 0.2 | 0.5 | 0.7 | |||||
| SBP | 0.5 | 0.95 | 0.6 | |||||
| 6 | rs12086676_C | 55738663 | C/T | 0.4 | 0.5 | |||
| DBP | −0.6 | 0.5 | 0.3 | |||||
| SBP | 0.06 | 0.9 | 0.95 | |||||
| 7 | rs12076372_A | 55738727 | A/C | 0.1 | 1 | |||
| DBP | −0.5 | 0.7 | 0.5 | |||||
| SBP | −1.7 | 1.3 | 0.2 | |||||
| 8 | rs6657064_G | 55738918 | G/C | 0.3 | 0.7 | |||
| DBP | −0.4 | 0.5 | 0.4 | |||||
| SBP | −0.9 | 0.97 | 0.4 | |||||
| 9 | rs2088487_T | 55739925 | T/C | 0.3 | 0.2 | |||
| DBP | −0.5 | 0.5 | 0.3 | |||||
| SBP | −0.5 | 0.95 | 0.6 | |||||
| 10 | rs17101343_C | 55741315 | T/C | 0.06 | 0.2 | |||
| DBP | 0.02 | 1.05 | 0.98 | |||||
| SBP | −2.0 | 1.9 | 0.3 | |||||
| 11 | rs6588555_A | 55741377 | A/G | 0.1 | 0.06 | |||
| DBP | 0.1 | 0.8 | 0.9 | |||||
| SBP | 0.02 | 1.4 | 0.98 | |||||
| 12 | rs12035319_T | 55742746 | T/C | 0.02 | 1 | |||
| DBP | 3.4 | 1.9 | 0.07 | |||||
| SBP | 1.9 | 3.4 | 0.6 | |||||
| 13 | rs2047418_G | 55743099 | G/C | 0.2 | 0.3 | |||
| DBP | −0.6 | 0.6 | 0.3 | |||||
| SBP | −0.6 | 1.0 | 0.5 | |||||
| 14 | rs1874776_C | 55743519 | T/C | 0.3 | 0.2 | |||
| DBP | −0.8 | 0.5 | 0.1 | |||||
| SBP | −0.7 | 0.96 | 0.5 | |||||
| 15 | rs2047420_T | 55744429 | T/G | 0.4 | 0.5 | |||
| DBP | −0.2 | 0.5 | 0.6 | |||||
| SBP | −1.6 | 0.95 | 0.1 | |||||
| 16 | rs4926675_A | 55744950 | A/G | 0.2 | 0.5 | |||
| DBP | 0.7 | 0.7 | 0.3 | |||||
| SBP | −0.2 | 1.1 | 0.9 | |||||
| 17 | rs11206551_A | 55744966 | G/A | 0.1 | 0.1 | |||
| DBP | −0.2 | 0.8 | 0.8 | |||||
| SBP | 0.7 | 1.5 | 0.7 | |||||
| 18 | rs12077573_G | 55746146 | C/G | 0.1 | 0.1 | |||
| DBP | −1.1 | 0.8 | 0.1 | |||||
| SBP | −2.0 | 1.4 | 0.1 | |||||
| 19 | rs12071742_A | 55747825 | A/G | 0.4 | 0.08 | |||
| DBP | 0.5 | 0.5 | 0.3 | |||||
| SBP | 1.6 | 0.95 | 0.08 | |||||
| 20 | rs17405810_C | 55748043 | C/G | 0.08 | 0.04 | |||
| DBP | −0.05 | 0.9 | 0.95 | |||||
| SBP | 0.4 | 1.7 | 0.8 | |||||
| 21 | rs9787035_C | 55748166 | C/A | 0.01 | 0.3 | |||
| DBP | −1.0 | 1.0 | 0.6 | |||||
| SBP | 2.2 | 3.6 | 0.5 | |||||
| 22 | rs17111836_T | 55748970 | T/C | 0.08 | 0.7 | |||
| DBP | 0.9 | 0.9 | 0.3 | |||||
| SBP | 1.6 | 1.7 | 0.3 | |||||
| 23 | rs4927218_A | 55749649 | A/G | 0.05 | 0.6 | |||
| DBP | −1.0 | 1.2 | 0.4 | |||||
| SBP | 1.5 | 2.1 | 0.5 | |||||
| 24 | rs9730100_C | 55750600 | C/A | 0.4 | 0.4 | |||
| DBP | 1.0 | 0.5 | 0.05 | |||||
| SBP | 1.3 | 0.9 | 0.2 | |||||
| 25 | rs4927219_A | 55751821 | A/G | 0.3 | 0.3 | |||
| DBP | 0.9 | 0.6 | 0.1 | |||||
| SBP | 1.1 | 1.0 | 0.3 | |||||
| 26 | rs17111859_T | 55752440 | T/C | 0.2 | 0.5 | |||
| DBP | −0.1 | 0.6 | 0.9 | |||||
| SBP | 1.3 | 1.1 | 0.2 | |||||
| 27 | rs17111863_C | 55752896 | C/T | 0.09 | 1 | |||
| DBP | 0.8 | 0.9 | 0.3 | |||||
| SBP | 2.3 | 1.6 | 0.1 | |||||
| 28 | rs11809596_A | 55753233 | G/A | 0.5 | 0.2 | |||
| DBP | 0.2 | 0.5 | 0.7 | |||||
| SBP | 0.9 | 0.9 | 0.3 | |||||
| 29 | rs17111872_C | 55755376 | C/G | 0.1 | 0.6 | |||
| DBP | 0.8 | 0.7 | 0.3 | |||||
| SBP | 2.0 | 1.3 | 0.1 | |||||
| 30 | rs17111875_C | 55757023 | C/A | 0.03 | 1 | |||
| DBP | 1.4 | 1.4 | 0.3 | |||||
| SBP | 3.2 | 2.5 | 0.2 | |||||
| 31 | rs10888912_A | 55757807 | A/G | 0.3 | 0.5 | |||
| DBP | 0.4 | 0.6 | 0.4 | |||||
| SBP | −0.3 | 1.0 | 0.8 |
*
Model adjusted for age, sex, center, smoking status, diabetes, and family random effect.
*A1, minor allele; β, regression coefficient; DBP, diastolic blood pressure; GWAS, genome-wide association study; HWE, Hardy-Weinberg Equilibrium; MAF, minor allele frequency; SBP, systolic blood pressure; SE, standard error.
Bold values signifies significant results at P ≤ 0.05.